Assistant Professor of Ophthalmology and Pathology

Education

University of Alabama at Birmingham, PhD

Duke University, Post-doctoral Fellowship

Phone

919.684.0820

Fax

919.684.8983

Email

gmalek@duke.edu

Research Interests

Goldis Malek, PhD, conducts research investigating the cellular mechanisms and pathobiology of retinal diseases with a focus on age-related macular degeneration. Currently she is using animal models, cell culture lines and genetic resources to study the molecular components of drusen formation and neovascularization, two key phenotypic characteristics of age-related macular degeneration.

Representative Publications

1. Edwards AO, Malek G. Molecular genetics of AMD and current animal models. Angiogenesis 2007;10(2):119-32. Epub 2007 Mar 13.

2. Yu L, Kelly U, Ebright JN, Malek G, Saloupis P, Rickman DW, McKay BS, Arshavsky VY, Rickman CB. Oxidative stress-induced expression and modulation of Phosphatase of Regenerating Liver-1 (PRL-1) in mammalian retina. Biochim Biophys Acta. 2007 Jun 26.

3. Malek G, Cousins SW. (2006) Is our current clinical classification of AMD up to the job? British Journal of Ophthalmology. Br J Ophthalmol. 2006 Sep;90(9):1080-1.

4. Malek G, Mace B, Saloupis P, Schmechel D, Rickman DW, Sullivan P, Bowes Rickman C. Initial observations of key features of Age-related macular degeneration in APOE targeted replacement mice. Retinal Degenerations: Mechanisms and Experimental Therapy. Adv Exp Med Biol. 2006;572:109-17.

5. Rosenthal R, Malek G, Salomon N, Coeppicus L, Wolleben H, Wimmers S, Bowes Rickman C, Strauss O. The fibroblast growth factor receptors FGFR-1 and FGFR-2 mediate two independent signaling pathways in human retinal pigment epithelial cell. Biochem Biophys Res Commun. 2005 Nov 11;337(1):241-7.

6. Malek G, Johnson LV, Mace B, Saloupis P, Schmechel D, Rickman DW, Toth CA, Sullivan P, Bowes Rickman C. Apolipoprotein E allele-dependent pathogenesis: Age-related retinal degeneration. PNAS. 2005 Aug 16;102(33):11900-5..

7. Curcio CA, Presley J, Malek G, Medeiros NE, Avery DV, Kruth HS. Esterified and Unesterified Cholesterol in Drusen and Basal Deposits of Eyes with Age-related Maculopathy. Experimental Eye Research. 2005 Jul 8.

8. Li CM, Chung BH , Presley J, Malek G, Zhang X, Dashti N, Li L, Chen L, Bradley K, Curcio CA. Lipoprotein-like Particles and Cholesteryl Esters in Human Bruch's Membrane: Initial Characterization. IOVS. 2005 46(7):2576-86.

9. Rosenthal R, Wohlleben H, Malek G, Schlichting L, Thieme H, Rickman CB, Strauss O. Insulin-like growth factor-1 contributes to neovascularization in age-related macular degeneration. Biochem Biophys Res Commun. 2004 29; 323(4):1203-8.

10. Malek G, Li CM, Guidry C, Medeiros NE, Curcio CA. Apolipoprotein B in cholesterol-containing drusen and basal deposits of human eyes with age-related maculopathy. American Journal of Pathology. 2003 162(2):413-25.