Professor of Ophthalmology and Pediatrics

Medical School

Harvard Medical School

Residency

University of Illinois, Chicago

Fellowship(s)

University of Pennsylvania

Sabbatical in Ophthalmic Genetics, Johns Hopkins Wilmer Eye Institute

Background

Terri Young, MD, specializes in the medical and surgical management of pediatric eye disorders and adult/childhood strabismus (eye misalignment). She has special expertise in the treatment of complicated ocular motility disorders secondary to cranial nerve palsies, thyroid ophthalmopathy, and trauma. She also has special expertise in the treatment of pediatric cataracts with and without intraocular implants, retinopathy of prematurity, and ophthalmic genetics. Young has developed a program in collaboration with Duke clinical geneticists to provide comprehensive care and evaluation of patients with genetic disorders with accompanying eye issues. She has written more than 95 scientific articles, book chapters, and reviews and has lectured extensively nationally and internationally. She has published and lectured widely on ophthalmic genetics, ocular motility disorders in children and adults, retinopathy of prematurity treatments and pathogenesis, craniofacial disorders, and pediatric cataracts. Young has received honor awards from the American Academy of Ophthalmology and the American Association of Pediatric Ophthalmology and Strabismus. She is a fellow of the American Ophthalmological Society, and the College of Philadelphia Physicians.

Phone

919.684.0584

Fax

919.684.6096

Research Interests

Young is an internationally recognized physician-scientist. She has established a state-of-the-art research program to determine underlying genetic causes of myopia (nearsightedness) and other inherited eye diseases, such as microphthalmia (small eye) and anophthalmia (absent eye). Her research receives support from the National Eye Institute at the National Institutes of Health, as well as private institutions such as Research to Prevent Blindness, Inc. Her team has identified the location of several major genes that cause the most severe forms of myopia, which may lead to retinal detachments, glaucoma, and premature cataracts. This information will ultimately lead to novel treatment approaches for this leading cause of blindness. 

Representative Publications

1. Paluru PC, Scavello GS, Ganter W, Young TL. Exclusion of Lumican and Fibromodulin as candidate genes in MYP3-linked high-grade myopia. Molecular Vision 2004; 10:917-922.
2. Young TL. Dissecting the genetics of human high myopia: A molecular biologic approach. Transactions of the American Ophthalmological Society 2004; 52:432-446.
3. Scavello GS, Paluru PC, Zhou J, White PS, Rappaport EF,Young TL. Genomic structure and organization of the high grade myopia-2 locus (MYP2) critical region: mutation screening of nine positional candidate genes. Molecular Vision 2004; 11:97-110.
4. DeScipio C, Schneider L, Young TL, Wasserman N, Yaeger D, Wheeler PG, Williams MS, Geschwindt R, Chudley AE, Saraiva J, Schinzel AA, Spinner NB, Krantz ID. Subtelomeric deletions of chromosome 6p; molecular and cytogenetic characterization of six new cases in three families with phenotypic overlap with Ritscher-Schinzel (3C) Syndrome. American Journal of Medical Genetics 2005; 134A:3-11.
5. Hutcheson KA, Paluru PC, Bernstein SL, Koh J, Rappaport EF, Young TL. Norrie disease gene sequence variants in an ethnically diverse population with retinopathy of prematurity. Molecular Vision 2005; 11:501-508.
6. Heidary G, Ying G-S, Maguire MG, Young TL. The impact of sphere on cylinder type and severity in a high myopia cohort. Optometry and Vision Science 2005; 82(4):244-247.
7. Zhou J, Young TL. Evaluation of Lipin 2 as a candidate gene for autosomal dominant 1 high-grade myopia. Gene 2005; 352:10-19.
8. Paluru PC, Nallasamy S, Devoto M, Rappaport EF, Young TL. Identification of a novel locus on chromosome 2q for autosomal dominant high-grade myopia. Investigative Ophthalmology and Visual Science 2005; 46(7):2300-2307.
9. Hoffman JD, Jacobson Z, Young TL, Kaplan P. Familial variable expression of dilated cardiomyopathy in Alstrom Syndrome: A Report of Four Siblings. American Journal of Medical Genetics 2005; 135A(1):96-98.
10. Nallasamy S, Kherani F, Yaeger D, McCallum J, Kaur M, Devoto M, Jackson LG, Krantz I, Young TL. Cornelia de Lange syndrome and ophthalmologic findings: A genotype-phenotype correlation study. (In press, Archives of Ophthalmology 2005)