Richard and Kit Barkhouser Professor of Ophthalmology

Chief, Glaucoma Service

Medical school

University of Cincinnati, College of Medicine

Residency

Eastern Virginia Medical Center

Fellowship

Harvard University, Massachusetts Eye and Ear Infirmary

Background

R. Rand Allingham, MD, specializes in the diagnosis and management of complex glaucoma. He is skilled in glaucoma laser surgical techniques including trabeculoplasty, iridotomy, and endoscopic cyclophotocoagulation. He has extensive experience with incisional glaucoma surgery, including trabeculectomy with antimetabolite therapy, revision of glaucoma filtering procedures, combined cataract and glaucoma surgery, and glaucoma implant surgery. He is consistently ranked in Best Doctors in America.

Phone

919.684.2975

Fax

919.681.8267

Research Interests

Allingham is an internationally recognized physician-scientist. He has established a state-of-the-art research program to determine underlying genetic causes of glaucoma and other inherited eye diseases. He works in close collaboration with scientists at the Center for Human Genetics located at Duke University. The research team includes world-renowned geneticist, Silke Schmidt, PhD, and molecular biologist, Michael Hauser, PhD, among others, at Duke University and other academic institutions. His research receives support from the National Eye Institute at the National Institutes of Health, as well as private institutions and philanthropic organizations. This team has identified the location of major genes that cause the most common forms of glaucoma. This information will ultimately lead to the discovery of methods to diagnose glaucoma rapidly and novel treatment approaches for this leading cause of blindness. Additionally, Allingham heads a team of scientists in developing a novel glaucoma implant for patients with glaucoma that does not respond to currently available medical or surgical treatment methods.

Representative Publications

1. Allingham RR, Wiggs JL, De La Paz MA, Vollrath D, Tallett DA, Broomer R, Jones KH, Del Bono EA, Kern J, Patterson K, Haines JL, and Pericak-Vance MA. Gln368STOP myocilin mutation in families with late-onset primary open-angle glaucoma. Invest Ophthalmol Vis Sci 1998:39:2288-95.
2. Wiggs JL, Allingham RR, Hossain A, Kern J, Auguste J, DelBono EA, Broomer B, Graham FL, Hauser M, Pericak-Vance M, Haines JL. Genome-wide scan for adult onset open angle glaucoma. Human Molecular Genetics 2000:9(7):1109-17.
3. Allingham RR, Seo B, Rampersaud E, Bembe M, Challa P, Liu N, Parrish T, Karolak L, Gilbert J, Pericak-Vance MA, Klintworth GK, Vance JM. A duplication in chromosome 4q35 is associated with hereditary benign intraepithelial dyskeratosis (HBID). Amer J Human Genet 2001:68:491-494.
4. Knepper PA, Mayanil CSK, Goosens W, Wertz RD, Holgren C, Ritch R, Allingham RR. Aqueous humor in primary open-angle glaucoma contains an increased level of CD44S. Invest Ophthalmol Vis Sci 2002:43(1):133-9.
5. Challa P, Herndon LW, Hauser MA, Broomer B, Pericak-Vance MA, Ababio-Danso B, Allingham RR. Prevalence of myocilin mutations in adults with POAG in Ghana, West Africa. J Glauc, 11:416-420, 2002.
6. Herndon LW, Challa P, Ababio-Danso B, Boateng JO, Broomer B, Ridenhour P, Allingham RR. Survey of glaucoma in an eye clinic in Ghana, West Africa. J Glauc 2002:11:421-425.
7. Asrani S, Challa P, Herndon L, Lee P, Stinnett S, Allingham RR. Correlation between retinal thickness analysis, optic nerve and visual fields in glaucoma patients and suspects. J Glauc 2003:12:119-128.
8. Allingham RR, Wiggs JL, Hauser EA, Larocque-Abramson KR, Santiago-Turla C, Broomer B, Del Bono EA, Graham FL, Haines JL, Pericak-Vance MA, Hauser MA. Early adult-onset POAG linked to 15q11-13 using ordered subsets analysis. Invest Ophthalmol Vis Sci, in press, 2005.
9. Knepper PA, Miller AM, Choi BA, Wertz RD, Nolan MJ, Goossens WG, Whitmer S, Yue BY, Ritch R, Liebmann JM, Allingham RR, Samples JR. Hypo-phosphorylation of aqueous humor sCD44 and primary open-angle glaucoma. Invest Ophthalmol Vis Sci, in press, 2005.